a change or variation occurring in the course of something.
interchange or alternation, as of states or things.
vicissitudes, successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs: They remained friends through the vicissitudes of 40 years.
regular change or succession of one state or thing to another.
change; mutation; mutability.
Origin: 1560–70; < L vicissitūdō, equiv. to viciss(im) in turn (perh. by syncope < *vice-cessim; vice in the place of (see vice3) + cessim giving way, adv. deriv. of cēdere to go, proceed) + -i- -i- -tūdō -tude